Query Metapaths Random Nodes
Return metapaths for a random source and target node for which at least one metapath with path count information exists in the database.
GET /v1/metapaths/random-nodes/?format=api
{ "source": { "id": 13579, "identifier": "4437", "identifier_type": "int", "name": "MSH3", "properties": { "url": "http://identifiers.org/ncbigene/4437", "source": "Entrez Gene", "license": "CC0 1.0", "chromosome": "5", "description": "mutS homolog 3" }, "metanode": "Gene" }, "target": { "id": 40129, "identifier": "WP1471_r82750", "identifier_type": "str", "name": "TOR Signaling", "properties": { "url": "http://www.wikipathways.org/instance/WP1471_r82750", "source": "WikiPathways", "license": "CC BY 3.0" }, "metanode": "Pathway" }, "path_counts": [ { "id": 13296193, "adjusted_p_value": 0.0022270258616906534, "path_count": 283, "dwpc": 1.892010627725295, "p_value": 4.7383528972141565e-05, "reversed": false, "metapath_abbreviation": "GeAdGpPW", "metapath_name": "Gene–expresses–Anatomy–downregulates–Gene–participates–Pathway", "metapath_length": 3, "metapath_path_count_density": 0.8381299999999999, "metapath_path_count_mean": 124.3, "metapath_path_count_max": 10352, "metapath_dwpc_raw_mean": 4.688e-05, "metapath_n_similar": 47, "metapath_p_threshold": 0.0005654360906725609, "metapath_id": "GeAdGpPW", "metapath_reversed": false, "metapath_metaedges": [ [ "Gene", "Anatomy", "expresses", "both" ], [ "Anatomy", "Gene", "downregulates", "both" ], [ "Gene", "Pathway", "participates", "both" ] ], "dgp_id": 32086357, "dgp_source_degree": 46, "dgp_target_degree": 36, "dgp_n_dwpcs": 772800, "dgp_n_nonzero_dwpcs": 772800, "dgp_nonzero_mean": 1.2263459983293856, "dgp_nonzero_sd": 0.1482891509456548, "dgp_reversed": false, "cypher_query": "MATCH path = (n0:Gene)-[:EXPRESSES_AeG]-(n1)-[:DOWNREGULATES_AdG]-(n2)-[:PARTICIPATES_GpPW]-(n3:Pathway)\nUSING JOIN ON n1\nWHERE n0.identifier = 4437 // MSH3\nAND n3.identifier = 'WP1471_r82750' // TOR Signaling\nAND n0 <> n2\nWITH\n[\nsize((n0)-[:EXPRESSES_AeG]-()),\nsize(()-[:EXPRESSES_AeG]-(n1)),\nsize((n1)-[:DOWNREGULATES_AdG]-()),\nsize(()-[:DOWNREGULATES_AdG]-(n2)),\nsize((n2)-[:PARTICIPATES_GpPW]-()),\nsize(()-[:PARTICIPATES_GpPW]-(n3))\n] AS degrees, path\nWITH path, reduce(pdp = 1.0, d in degrees| pdp * d ^ -0.5) AS PDP\nWITH collect({paths: path, PDPs: PDP}) AS data_maps, count(path) AS PC, sum(PDP) AS DWPC\nUNWIND data_maps AS data_map\nWITH data_map.paths AS path, data_map.PDPs AS PDP, PC, DWPC\nRETURN\n path AS neo4j_path,\n substring(reduce(s = '', node IN nodes(path)| s + '–' + node.name), 1) AS path,\n PDP,\n 100 * (PDP / DWPC) AS percent_of_DWPC\nORDER BY percent_of_DWPC DESC\nLIMIT 10" }, { "id": 147819240, "adjusted_p_value": 0.002908523721824169, "path_count": 223, "dwpc": 1.8357675422727966, "p_value": 6.188348344306743e-05, "reversed": false, "metapath_abbreviation": "GeAuGpPW", "metapath_name": "Gene–expresses–Anatomy–upregulates–Gene–participates–Pathway", "metapath_length": 3, "metapath_path_count_density": 0.8334219999999999, "metapath_path_count_mean": 123.65899999999999, "metapath_path_count_max": 8985, "metapath_dwpc_raw_mean": 4.93454e-05, "metapath_n_similar": 47, "metapath_p_threshold": 0.0005654360906725609, "metapath_id": "GeAuGpPW", "metapath_reversed": false, "metapath_metaedges": [ [ "Gene", "Anatomy", "expresses", "both" ], [ "Anatomy", "Gene", "upregulates", "both" ], [ "Gene", "Pathway", "participates", "both" ] ], "dgp_id": 32387857, "dgp_source_degree": 46, "dgp_target_degree": 36, "dgp_n_dwpcs": 772800, "dgp_n_nonzero_dwpcs": 772800, "dgp_nonzero_mean": 1.2380046072355437, "dgp_nonzero_sd": 0.13725627762055062, "dgp_reversed": false, "cypher_query": "MATCH path = (n0:Gene)-[:EXPRESSES_AeG]-(n1)-[:UPREGULATES_AuG]-(n2)-[:PARTICIPATES_GpPW]-(n3:Pathway)\nUSING JOIN ON n1\nWHERE n0.identifier = 4437 // MSH3\nAND n3.identifier = 'WP1471_r82750' // TOR Signaling\nAND n0 <> n2\nWITH\n[\nsize((n0)-[:EXPRESSES_AeG]-()),\nsize(()-[:EXPRESSES_AeG]-(n1)),\nsize((n1)-[:UPREGULATES_AuG]-()),\nsize(()-[:UPREGULATES_AuG]-(n2)),\nsize((n2)-[:PARTICIPATES_GpPW]-()),\nsize(()-[:PARTICIPATES_GpPW]-(n3))\n] AS degrees, path\nWITH path, reduce(pdp = 1.0, d in degrees| pdp * d ^ -0.5) AS PDP\nWITH collect({paths: path, PDPs: PDP}) AS data_maps, count(path) AS PC, sum(PDP) AS DWPC\nUNWIND data_maps AS data_map\nWITH data_map.paths AS path, data_map.PDPs AS PDP, PC, DWPC\nRETURN\n path AS neo4j_path,\n substring(reduce(s = '', node IN nodes(path)| s + '–' + node.name), 1) AS path,\n PDP,\n 100 * (PDP / DWPC) AS percent_of_DWPC\nORDER BY percent_of_DWPC DESC\nLIMIT 10" }, { "id": 150430179, "adjusted_p_value": 0.005220400069579087, "path_count": 1225, "dwpc": 1.654943405255587, "p_value": 0.00011107234190593803, "reversed": false, "metapath_abbreviation": "GeAeGpPW", "metapath_name": "Gene–expresses–Anatomy–expresses–Gene–participates–Pathway", "metapath_length": 3, "metapath_path_count_density": 0.8626309999999999, "metapath_path_count_mean": 665.92, "metapath_path_count_max": 55830, "metapath_dwpc_raw_mean": 7.12822e-05, "metapath_n_similar": 47, "metapath_p_threshold": 0.0005654360906725609, "metapath_id": "GeAeGpPW", "metapath_reversed": false, "metapath_metaedges": [ [ "Gene", "Anatomy", "expresses", "both" ], [ "Anatomy", "Gene", "expresses", "both" ], [ "Gene", "Pathway", "participates", "both" ] ], "dgp_id": 32233057, "dgp_source_degree": 46, "dgp_target_degree": 36, "dgp_n_dwpcs": 772800, "dgp_n_nonzero_dwpcs": 772800, "dgp_nonzero_mean": 1.235660333797718, "dgp_nonzero_sd": 0.10353677305531254, "dgp_reversed": false, "cypher_query": "MATCH path = (n0:Gene)-[:EXPRESSES_AeG]-(n1)-[:EXPRESSES_AeG]-(n2)-[:PARTICIPATES_GpPW]-(n3:Pathway)\nUSING JOIN ON n1\nWHERE n0.identifier = 4437 // MSH3\nAND n3.identifier = 'WP1471_r82750' // TOR Signaling\nAND n0 <> n2\nWITH\n[\nsize((n0)-[:EXPRESSES_AeG]-()),\nsize(()-[:EXPRESSES_AeG]-(n1)),\nsize((n1)-[:EXPRESSES_AeG]-()),\nsize(()-[:EXPRESSES_AeG]-(n2)),\nsize((n2)-[:PARTICIPATES_GpPW]-()),\nsize(()-[:PARTICIPATES_GpPW]-(n3))\n] AS degrees, path\nWITH path, reduce(pdp = 1.0, d in degrees| pdp * d ^ -0.5) AS PDP\nWITH collect({paths: path, PDPs: PDP}) AS data_maps, count(path) AS PC, sum(PDP) AS DWPC\nUNWIND data_maps AS data_map\nWITH data_map.paths AS path, data_map.PDPs AS PDP, PC, DWPC\nRETURN\n path AS neo4j_path,\n substring(reduce(s = '', node IN nodes(path)| s + '–' + node.name), 1) AS path,\n PDP,\n 100 * (PDP / DWPC) AS percent_of_DWPC\nORDER BY percent_of_DWPC DESC\nLIMIT 10" } ], "n_metapaths": 3, "pathcount_table_random_id": 150430179, "pathcount_table_max_id": 169602979 }